Side effects to this combination includes hives and itchy rashes,dizziness,nausea, drowsiness, flushing, vision changes, or mental/
mood changes,chest tightness,difficulty breathing etc.
Pls stop this drug and take her to the doctor immediately.She needs to have oral or I/V steroids and antihistaminics immediately.Take her as soon as possible so that life threatening anaphylaxis can be avoided.
Hope it helps.Take care and pls do keep me posted on how your wife is doing.