Metformin renal dosing

Common Questions and Answers about Metformin renal dosing

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Avatar f tn Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested. The followings are extracts from the label information for Tenofovir: 2.3 Dose Adjustment for Renal Impairment in Adults Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
Avatar n tn I guess metformin is working because when the egfr is 60 mean you have chronic kidney disease, its good that you done your egfr blood test and got to know this earlier.
Avatar f tn I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate). This is from Clinical Care Options @ http://tiny.
Avatar f tn After taking metformin for a year it was found I was in stage 3 renal failure. I got taken off of metformin my kidneys showed improvement, then they put me back on it again my kidneys showed problems. I was taken off of it again and again my kidney function showed signs of improvement. I was put in metformin a 3rd time and within 3 months my kidneys showed issues again. I will never take this drug again and am looking for a lawyer to represent me.
Avatar m tn 00 am, you could take the metformin around noon....... Talk to your doctor to be sure.
Avatar f tn I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
Avatar m tn I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference: According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
Avatar n tn For the long-acting form, metformin ER, the starting dose is metformin ER 500 mg once daily, and the maximum dosing is metformin ER 2000 mg once daily (or metformin ER 1000 mg twice daily).
Avatar f tn //pain-topics.org/pdf/Opioids-Renal-Hepatic-Dysfunction.
Avatar m tn With all of this, they still want me to take 500mg of Metformin ER (at breakfast and dinner, so 1000mg per day). First, think another A1C may be in order a couple months after surgery to act as a validator with these normal BG numbers? Second, is it usual to have the ER version of Merformin initially perscribed? Isn't there a non-ER version that is more common?
Avatar n tn Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age. Take care and keep us posted.
Avatar n tn My doc put me on Provera to induce a period. I just started mine last monday and I started bleeding yesterday. It worked for me before I even finished taking the 10-day dosing. I just had a bad experience taking Metformin so I can't really recommend that but lots of ladies here have had great experiences with the Metformin. Good luck!
1660049 tn?1326089018 what formulation of metformin are you taking? My book says usual dosing is 500mg twice daily to start up to a maximum of 2550mg for regular metformin. Extended release has a lower maximum daily dose.
Avatar m tn I posted about this a few weeks back about Metformin and here is the whole article about it. It is very interesting that a diabetes drug has been found to combat cancer and HCV. There are probably many other drugs already approved that could also help different diseases if used "off label". Usually these things are found out by accident. http://www.lef.org/magazine/mag2010/nov2010_The-Drug-Virtually-Everyone-Should-Ask-their-Doctor-About_01.
Avatar f tn His glucose level has been over 200 for the last 5 years. He is taking 2000 mg of metformin, and 20 glipozide. It is not working. He has to be under 200 in order to drive, so he has really been eating correctly this week and checking and checking maybe double dosing medications. His level bounces up and down 50 points within 10 minutes of the last checking. Is it normal to go up and down so rapidly? We are using 2 checkers to make sure there wasnt a malfunction.
Avatar m tn I was recently diagnosed with congestive heart failure after a brief stay in the hospital (admitted from the ER with chest pains). I was given several tests, including an echocardiogram and a nuclear stress test.
427265 tn?1444076436 Has anyone's Dr. recommended double dosing? I was under the assumption that it was a personal choice people made and did on their own. If I don't decide to go with a trial, my Dr. wants me to double dose peg 180 mg 2x per week and 1400-1600 copeg (weight based) for 4 weeks. If RVR at 4 weeks, continue SOC for a total of 48 weeks. If no RVR, continue double dosing until week 12, the SOC to 72 weeks.
Avatar m tn There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them. With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
Avatar m tn But regarding this Vit D , should i need to take along with calcium supllements Or no need? I have renal stones of 0.5mm. Does this have any effect on this?
Avatar n tn However, it is common practice to increase medication dose to help control blood sugar (the maximum dose of metformin is about 2500 mg/day, in split doses). Some people do take their medication before eating. Please discuss changes in medication dosing with your md. You may also find that restricting carbs (eat more fat, non-starchy vegetables instead to replace the calories) may help in reducing your blood sugar.
1500387 tn?1460740020 •Having kidney problems, including kidney failure (renal failure) •Having liver problems, including liver failure or cirrhosis •Having congestive heart failure (CHF) •Having a procedure using contrast dye (see Metformin and Contrast Medium) •Drinking large amounts of alcohol on a regular basis (see Metformin and Alcohol) •Drinking a large amount of alcohol at one time (binge drinking).