[6] Additionally, there are numerous reports using
metformin for the treatment of
gestational diabetes mellitus (GDM), without evidence of fetal harm.[7-9] Although metformin does cross the placenta, a partial placental barrier likely exists, as maternal and fetal concentrations are different.[5,6,10]
Several studies have reported an increased risk of spontaneous abortion in women with PCOS, perhaps 20% to 40% higher than in the general obstetric population.