The addition of dexamethasone, to a clomiphene regimen may increase the likelihood of ovulation by suppression of ACTH and any circulating adrenal androgens.
For women who are unresponsive to clomiphene,the oral hypoglycemic agents like metformin could be of little help, or pioglitazone, may bring resumption of regular cycles and ovulation. These agents reduce the hyperinsulinemia and hyperandrogenemia in PCOS.
These are actually medically prescribed medicines for PCOS.