The role of metformin in ovulation induction is well established, and several studies have demonstrated that women with PCOS are more likely to ovulate with metformin than with placebo alone.[2, 4] Therefore, women with PCOS often conceive while on
metformin, and exposure
during organogenesis is common. At present, metformin is classified as Class B in pregnancy, with no evidence of animal or fetal toxicity or teratogenicity.