Tri-Sprintec typically causes nausea, bloating, stomach cramps, breast
pain, vaginal discharge,
menstrual irregularities and changes in your appetite and weight. Tri-Sprintec can affect your appearance and cause increased hair growth, loss of hair or freckling of your skin. It can cause nervousness, a headache and fatigue. These side effects are fortunately rather benign. However, they may become bothersome if they last for more than three days.