OMG!! 46, will be 47 in June. Can't even tell you how everything seems to be failing, wrinkling, etc. & yes, it seems like it happened overnight. Perimenopausal as well. Had complete check up recently & no major health issues. However, my gyno has me hrt's(which I REALLY want to get off of). Added into the mix of all the skin issues mentioned, I am losing my hair like CRAZY. Anyone else having hair loss issues?