We all have different pain thresholds and you may be able to handle pain a lot better than me, for example. What I can tell you is that as my stones start to make themselves known, I can handle the pain somewhat as it builds up. After a certain point though, there is no way I can handle it and in fact, normal pain meds like Hydro 10's won't help me very much, for very long! I must get to an emergency room and get a pain shot of something that kills the pain, because it's that bad.