how does naloxone work

yes, it does block. the naloxone in suboxone is only there to prevent misuse by IV addicts/abusers, that is naloxones only purpose...buprenorphine is the blocker, so to speak .. you would have to be off either one before your procedure...good luck!!

i thnk that it is a good helper but only for maintence not long term i was takn 50+ a day or norcos for 7 yrs and i am takn sub but i am weaning off it as fastly as i can started at like 24 mgs i now am only taking 4 mgs so i recomend to use it but not long cause it does work with cravings and w/ds but u dont wana get hooked on that so if used properly i reccomend it good luck hope i helped a lil.

i was on 32 mgs daily for 8 mths and the got off due to ana ccident and now am in a methaodne treatment, but let me know your sub info and i get better help aid you explaining the wd;s and all the questions the how long? how bad? when will it peak or get less bad? etc..

I would be interested to know how that method spitting it out prevents the naloxone from entering the digestive track

a friend used the morning she went to the sub doctor and he started her on subutes immediately as it does not have the naloxone in it....it is possible u may have to miss work the day of ur appt with the sub doctor but many do not and go in afterwards...but i would take that day off so u can see how it will affect u...try to start out at the lowest dose possible of sub as many doctors will want to put u on a large amount and it will make u drowsy and unable to work...

naloxone will have no effect what so ever on you so the idea, which i understand where youre coming from of "just another med" does not work for naloxone...it is a great idea by your therapist, it will just ensure that if your having a really rough day and have a lapse in judgment and use a few pills that youll know in the back of your head that it is absolutely impossible to get high on any amount or any potency opiate...

Thank you! I just don't understand how I can abuse something that does not produce a high? I take just enough suboxone so that I don't go into WD or experience chronic pain- so I can function. I am not an IV user and don't plan on becoming one. I'm wondering If the Naloxone mixed with Prozac and Topamax are causing my depression to worsen? I'm trying to minimize my medication intake.

How long does heroin withdrawals last? Ive been clean for a week and I took a suboxne after the second day.

Doing the same with Suboxone will either make you sick as a dog because of the added naloxone...or have you feel nothing at all. Every drug available can and will be abused. Just how our minds work.

I thought it might be nice to keep some around, but really, I would like to take it to help speed up WD. Does anyone know if this would work, or if it is possible? I am not concerned with the pain it would cause, in my mind, its better to have one hard punch to the face than several small kicks to the groin. Opinions?

Im sure they are both the same drug. The suboxone has naloxone in it to deter people from shooting it. The naloxone doesnt have any affect on you. So I dont see why you would feel any different. Unless you are taking less. Are they both 8 mg pills?

My friend was put on Zubsolv which apparently is similar to Suboxone. Any information would be approximated. More so on does it work the same? Is the strength comparable?

Hello Rhonda, I am glad that you found us at the Pain Mangement Forum of MedHelp. We often struggle with tolerance and finding the right medication that will control our chronic pain. What works well for one person will not necessarily work well for another. It's usually trial and error. Has your physician suggested Opana ER? It's worth a try. As Mollyrae suggested some ppl find that the fentanyl patch works well for them. You have several choices.

Actually, the naloxone in suboxone is innert when taken properly. It does absolutely nothing. When taken properly, the buprenorphine has a higher affinity than the naloxone, and occupies all the opiate receptors. The Naloxone is metabolized and secreted out of the body-wasted.

One of the reasons I went on it, besides my insane addiction to lortab, was needing something that controlled my pain without making me high. For ME sub does this. does not work for everyone though. When I do finally quit, it will be under a physicians supervision, and will be extremely slow taper. Now, am I a cured addict??? HELLL NO. I will always be an addict.

Suboxone is typically used for addiction, and contains naloxone. You MUST be in moderate withdrawal before using it, scoring I believe a 26 on the scale before taking any of it. Otherwise you can be thrown into Precipatated withdrawal . I would suggest discussing this with your PM doctor before considering this option. Some have gotten relief, most have not.

what physical w/d does not really get me..

So I disagree with Jay where he says the nayloxone occupies the opioid receptors when taken oraly. It does not. Naloxone is present in Suboxone to discourage misuse, only. It serves no other purpose. When injected however, the Naloxone will react with any agonist in a persons system, causing percipitated withdrawal. It would not react with any bupe in the system however. While Naloxone has a high afinity to the mu opioid receptor, it's not as high of an affinity as buprenorphine.

Mamasago! Let us know how the week has been? How are you? How are you feeling? How is the "process"?

i am allergic to naloxone (the opiate blocker in suboxone). i dont wanna get on methadone cuz the addiction gets serious. is there any thing like suboxone with the naloxone in it?

However many individuals who start using it to treat their addiction, become addicted to Suboxone itself. Having said that it is still a viable option and does work for some people as a tapering tool off of opiates. Obviously it did not work for your husband and he got addicted. I personally prefer our method of getting clean: just get done with it. We get people through withdrawals under deep sedation and start them on a Naltrexone therapy with an implant that will last two month.

However many individuals who start using it to treat their addiction, become addicted to Suboxone itself. Having said that it is still a viable option and does work for some people as a tapering tool off of opiates. But you are saying that you are already feeling relatively well off of methadone, so why would you want to go back on an opiate again, may be you can just continue and stick it out and be drug free?

☺ Bubba, I was told by one of my doctors (I swear last year I had 2 doctors, now I have like 5 or 6) that the Naltrexone DOES work against cravings too, actually I was prescribed it for that reason, but I never took it because I was scared I was taking too many different drugs. LOL.

So back to the subject I had taken this to try and lose some of this weight or water weight or whatever is going on and it barely worked (and if Uve taken this b4 u know how strong it is and how it makes u **** out of ur *** lol) so for it to not work that scared me maybe the next day I went like once or twice instead of it emptying me out so idk what that was about regular laxatives do nothing, so my digestive system is at a very very slow crawl, legit will go a week or maybe two before I hav

An antagonist is an agent that binds to a receptor but does not elicit the response that the neurotransmitter or an agonist would cause. The antagonist blocks the receptor and prevents activation by neurotransmitters or other drugs. So in the case of opiates, lets look at the opiate agonist Morphine. When Morphine enters the brain, it binds to opioid receptors and activates them. This binding is what produces the effects of Morphine.

How does naloxone work

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