I too am on the vivelle dot patch, I change mine every 2 days and also take estradiol one tab at bedtime. I am like a new person. I think they have finally gotten my
hormone replacement right. I must say that premarin is one of the older, not so good hormone replacement products available. There are so many new and safer bioidentical hormones on the market like the vivelle. I would go back to my doc, get your hormone levels checked and demand to be put on one of the safer replacements.