Other commonly recognized risk factors include kidney disease
, homocysteinemia, increased Lp(a), apo-B mutations, post-menopausal status, among others. More controversial but possible associated factors leading to heart disease include autoimmune disease, chronic infections, obesity, and others.
An annual physical for a 40 yo male that includes lipid profile, EKG, and basic chemistries are recommended. This exam will not "rule out" every disease, not should it.