38 Previously, various studies including the Controlled High Risk Avonex, Multiple Sclerosis Study, the Early Treatment of
Multiple Sclerosis Study, the Betaseron in Newly Emerging
Multiple Sclerosis for Initial Treatment Trial, the Prevention of Relapses and Disability by Interferon β-1a Subcutaneously in Multiple Sclerosis, and PreCISe trials have all helped to clarify the natural history of CIS including ON and management options for a single demyelinating episode.