I"m also 45 and am doing it naturally, if your wife is still having regular periods, thats good, if you want to give it a go naturally you should look at egg health, get on some royal jelly capsuals, coq10 up to 600mg daily, a good fish oil, I'm on maca which nourishes the endochrine system and helps with hormones and also look into dhea suppliments, 3x 25 tab per day, as eggs take approx 3 months to mature you should be on these for at least 3 months, plus a good preconception vitamin