Gabapentin renal dosing
Common Questions and Answers about Gabapentin renal dosing
neurontin
Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
After 30+ years of developing a chronic cough which would last for about 4-5 months following every upper respiratory infection and being prescribed antibiotics, allergy medication, inhalers, steroids, to no avail, within 3 days of being prescribed GABAPENTIN and TRAMADOL, his cough was immediately arrested.
My 5 year old son had an upper respiratory infection, followed by a throat clearing tickle and a dry persistent cough. Now, 3 months later, he is still coughing.
So my dr gave me gabapentin for tramadol withdrawals. It has helped wonderfully. This was 7 days ago. So I think I am over the withdrawals from the tramadol but I have been taking high doses of gabapentin in that 7 days. Like anywhere from 900-1800mg a day to stave off withdrawals. My question is how long will it take to develop a gabapentin addiction because I've read horror stories about the withdrawals.
Due to brain damage from surgery I have temporal lob seizures I was put on gabapentin and depression occurred. I am looking for something that would control the seizures without depression. Help with any idea! Thanks
Would Dilatin help with this type of seizure?
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
I have chronic kidney stones and renal colic in my left kidney, which in its self is full of scar tissue and tech non functioning. I have been on and off pain medication for the last two years. Between several surgeries for my kidney, lungs and my tubes tied for medical reasons. In the time span of three months I had been on Narco 5/500 1-2 tablets every four to six hours as needed. Just this past week I have started healing and trying to get back to normal after 4 surgeries in just 6 weeks.
Most patients require one or two dose titrations of the long-acting opioid medication before the dosing is considered optimal. Optimal dosing is achieved typically when the patient requires no more than 2-3 doses of breakthrough pain medication per day.
We wish you the best and please let us know how your appointment goes. Take care.
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
After acquiring a rare reverse side effect from taking gabapentin, I now have skin & mouth burning sensation which is VERY difficult to deal with. After doing research, I found vitamin B may be the answer and taking a large dose of b12 has helped many people with the mouth burning issue. I think it is helping me too, but when I take it, my heart rate seems to drop - 61 bpm -- which doesn't feel right to me.
After acquiring a rare reverse side effect from taking gabapentin, I now have skin & mouth burning sensation which is VERY difficult to deal with. After doing research, I found vitamin B may be the answer and taking a large dose of b12 has helped many people with the mouth burning issue. I think it is helping me too, but when I take it, my heart rate seems to drop - 61 bpm -- which doesn't feel right to me.
The amount of mannitol in Copaxone is small and absorption
Gabapentin (Neurontin) should be used carefully in patients with renal impairment due to possible accumulation and toxicity. It has been linked with liver toxicity.
Provigil is metabolized by the liver and excreted in the urine.
Have they looked for an independent cause? Some simple blood and urine tests can provide a lot of information about kidney function and possible causes.
When I first starting taking gabapentin the dose was 400mg each night. I was supposed to add a morning dose the second week and then an afternoon dose in the third week. I was getting relief with the 400mg bedtime dose alone but it made me so sleepy that I didn't dare take it during the day.
My GP suggested I stick with the once daily dosing for a while. She told me that many of her patients never have to add daytime doses to get adequate pain control.
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
Hello all, I appreciate reading everyone's posts.
I'm not diagnosed w MS or being officially evaluated for it, but I seem to be having increasing symptoms that point in that direction.
I'm currently taking Detrol, Tramadol & Gabapentin for my symptoms. I have an 8+ year history of low back pain which moved from myofascial pain to facet joint issues to sciatica-type problems. In addition to lots of pain I have increasing weakness in my legs, tripping / stumbling etc.
However, NSAIDs cause pronounced declines in the renal function within hours in the stressed kidney by reducing the renal plasma flow and glomerular filtration rate, according to the National Center for Biotechnology Information. (See References 2) Furthermore, prolonged use of NSAIDs increase the risk of permanent renal damage in patients with already impaired renal function, adds the National Center for Biotechnology Information (See References 2)
Read more: http://www.livestrong.
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