Fitness journal template

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181575 tn?1250202386 268-274. Full paper in http://www.sciencedirect.com/science/journal/15423565 1. Monotherapy using lamivudine has the longest history of use and shows highest rate of resistance. A 2003 study of 998 patients showed 65% lamivudine-resistance mutations in 5 years. Lamivudine should no longer be used as monotherapy. 2. Monotherapy using adefovir has 29% mutation probability in 240 weeks, according to a 2006 study of 125 patients. 3.