I have a good friend who unfortunately, has become a Zombie from his 14 medications,with multiple significant interactions, and
a gazillion side effects
nobody has bothered to look into any of those interactions and effects.
It all started with a heart attack , then got a little depressed, developed some indigestion, experienced back pain, got a little constipated, couldn't sleep well at night and the rest is history. He's never going to enjoy his life again, like before.