Fentanyl and histamine release
Common Questions and Answers about Fentanyl and histamine release
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I have been have been having huge histamine releases in my body (Checked by ER) to the point my whole body aches and my lungs hyper expand making it extremely difficult to breathe. I just got the results from my allergy test - NEGATIVE - Now no one seems to know what to do? Has anybody experienced this? Thanks.
Certain factors can trigger the release of histamine and the other chemicals from mast cells and this includes drugs (especially aspirin and other non-steroidal anti-inflammatory drugs, codeine and morphine, and some anaesthetics), alcohol, emotional stress, physical stimuli (heat, exercise and friction), bacterial toxins and insect venom. Liposuction is a physical stimulus and can trigger histamine release.
Hydromorphone and fentanyl appear to be the least affected by renal dysfunction, and fentanyl has less hemodynamic disturbance (due to lack of histamine release associated with other opioids).39"
"NSAIDs and opioids may be used at reduced doses in patients with chronic liver disease without cirrhosis. Patients with cirrhosis have fewer analgesic options.
On yahoo answers...... (sounds good)
"You've got lots of good advice here and I just had to add mine because I suffer from hives-- diagnosed as 'ideopathic urticara'- for months at a time.
The best advice my dermatologist ever gave me: Don't scratch. When you scratch your cells burst and release histamines... you may find yourself swollen. I have had this condition to the point of being disfigured and in the ER being pumped full of steroids.
Some opiates cause histamine release-- particularly morphine-- that can cause itching and a rash. Some high-potency synthetic opiates--namely fentanyl and sufentanil-- cause facial itching, particularly around and inside the nose. Some medications can cause a feeling of extreme restless called 'akathesia' that sometimes presents as intense itchiness over the body, especially the legs.
Quercetin inhibits the production and release of histamine and other allergic/inflammatory substances. Histamine is a substance that is responsible for the allergic symptoms in the body. It can be taken in natural form by consuming apples and red onions and is also available as a dietary supplement.
You may discuss this with your healthcare provider for dosage and other instructions.
I was on the fentanyl patch many years ago, but for several years, and at a high dose. After developing diabetes, my body temperature made the medicine enter my body too quickly and so created problems. At that time, there wasn't the option of oral - only IV. The only question I'd have is that the GI tract absorbs medicines in oral liquid form quite quickly - unless in a time release form - thereby reducing the slow release quality of the patch.
I have been on Fentanyl patches for about 6 months and it was prescribed to wean me off of Norco 10/325 2 pills 4 x day after a surgery. I got as high as 75 mcg patch of Fentanyl every 3 days and then I developed some kind of allergy. The Pain Dr. says the allergy is to the adhesive, not the fentanyl. I am now down to 37 mcg every 2 days because the patches itch like crazy. I wake up in the morning and my patches are scratched off(even withTagederm) and there is blood on my sheets. My Dr.
Hives develop in response to an allergic reaction, by the release of histamine. The allergen can be medications, food, extremes of temperature, exercise and viral infections to name a few. Since you developed the outbreak along with joint pains and fever, it could be a response to an infection. So, therapy lies in resolving the infection and anti-histamines. If the present antihistamines are not very effective you can consult your doctor for long acting ones.
When ever you are exposed to allergen there will be release of histamine, this is responsible for raised lesions on skin leading to itching. The order may differ from individuals to individuals.
You need to identify such allergen and prevent further exposure. Oral anti histamines and low potency corticosteroids will help to reduce the symptoms. I suggest you to consult allergy specialist. Take care and regards.
Whenever you are exposed to allergen there will be release of histamine, this is responsible for sneezing first and then followed by further release of histamine in the skin leading to itching, runny nose, watery eyes etc. The order may differ from individuals to individuals.
You need to avoid contact with allergen to avoid further complications. Also treatment includes anti histaminic and glucocorticoids against prescription.
Morphine ER is an extended release- most taking it don’t feel it ‘kick in’ like the immediate release options and often believe because they don’t ‘feel it’ it’s not working. Extended release meds are meant to deliver a steady blood stream level of medication over its dosage time.
Fentanyl is hundreds of times MORE POTENT and powerful than other opiates and is absorbed through the skin- over three days.
The mast cell tissue release Histamine which spread to the air by some ways which cause allergic phen—.And I think the mast cell tissue is highly related to brown adipose tissu.Brown adipose is distributed in scapula,shoulder,neck, perineumIt.So,you might feel burning and scratch frequently in these place.Generally,I thought the instinct of PATM caused by histamine is immune system problem.So lots of people also suffer from rheumatic arthritis when they grow old.
The tricyclic antidepressant doxepin has also been found to be an effective blocker of histamine release. Finally, a medication called ketotifen, which keeps mast cells from releasing histamine, has also been used with success.
ref:http://www.healthatoz.com/healthatoz/Atoz/common/standard/transform.jsp?requestURI=/healthatoz/Atoz/ency/physical_allergy.jsp
ref:http://dermatology.about.com/cs/hives/a/coldurt.
I have also copied this down and for more information we have a Dermatology forum on MH Triggers for Mast Cell Disease
Physical stimuli: Exercise, heat, skin friction, hot baths, hot drinks, cold exposure (especially swimming), sunlight, emotional stress, spicy foods.
Hi,
Hives are caused by inflammation in the skin and can be triggered when certain cells in the body release histamine and other chemicals into your bloodstream and skin. This may be caused by allergic reactions to medications or foods or other allergens.Additional triggers include physical factors such as environmental factors ( heat, cold, sunlight, water, pressure on the skin, emotional stress and exercise). Preventing the triggers will help prevent the symptoms.
- MS Contin (Extended Release Morphine),
- Nucynta ER (ER Nucynta)
- Ultram ER (ER Tramadol, brand)
- Opana ER (Extended Release Oxymorphone)
- OxyContin (Extended Release Oxycodone)
- Exalgo (ER Dilaudid)
- BuTrans Patch (ER Buprenephrine)
- Fentanyl Patch (ER Fentanyl)
MS Contin, Opana ER, and OxyContin are typically prescribed 2-3 times per day or every 8 to 12 hours. Exalgo is prescribed every 24 hours. The BuTrans patch last 7 days and the Fentanyl patch lasts 48-72 hours.
Any narcotic should, if possible, be slowly tapered as physical withdrawal is quite unpleasant. I did a fast taper that was not supervised by my doctor and it was less than ideal. Fentanyl can be a bit harder than Percocet, Vicodin, etc. Drinking lots of water is essential as it is really easy to get dehydrated. You can taper from the Fentanyl down and then cross over to a different immediate release narcotic and then taper down from that.
Are you taking anything else?
Trauma may release an antigen that interacts with the membrane-bound immunoglobulin E of mast cells, which release inflammatory mediators, particularly histamine, into the tissues. This causes small blood vessels to leak, allowing fluid to accumulate in the skin
It can be treated by antihistamines or cromoglicate and sometimes steroids, as they prevent the histamine from causing the reaction. As the underlying cause of dermographism is not known, it can last for many years without relief.
Indeed Morphine is known to trigger asthma in some ppl. Actually morphine can trigger an attack because of histamine release. Histamine is a potent bronchocontrictor thus has the potential to induce an asthma attack.
There are multiple opiates that may be more effective and appropriate for you, especially given you have asthma. I am not a physician - and to suggest a specific medication for you would not be prudent.
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