Ezetimibe simvastatin
Common Questions and Answers about Ezetimibe simvastatin
zetia
no study for its activity on hbv, we do know it has activity but the trial has never started
simvastatin lowers hcc 50% and prevents fibrosis/cirrhosis so it is indicated on all hbver, this has thousands of pateints studied for decades to find this data on hcc
you better use simvastatin instead other statins, also ezetimibe has in vitro effect on hbv so these are the best choices on hbvers
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
curious if stef2011 or studyforhope or StephenCastlecrag know whether simvastatin by itself can reduce viral load? I've read about the effects in conjunction with NUCS but I'm curious if sim is effective alone.
There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor.
Best of luck to you. Stay positive.
Advicor (lovastatin/niacin extended-release), Simcor (simvastatin/niacin extended-release), and Vytorin (simvastatin/ezetimibe).
Crestor is a statin (rosuvastatin calcium) only, Vytorin is a statin (Simvastatin) with Zetia (ezetimibe). Statins work by controlling the production of cholesterol in your liver while Zetia works by preventing cholesterol to be absorbed in your digestive system.
Of the two, Crestor is the stronger of the two. In addition, recent trials have shown that adding Zetia does not improve the performance of Vytorin over Simvastatin alone.
Generally, if you experience muscle weakness as a side effect of Lipitor (atorvastatin), other statins will produce similar effects, so that eliminates the use of Zocor (simvastatin), Crestor (rosuvastatin) etc.
After statin therapy fails or is not tolerated, it is normal to try ezetimibe (Zetia), which you said did not work. The use of colesevelam (WelChol) is not high, and is often the 'last ditch effort' to lower cholesterol.
A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
The FDA-approved drug ezetimibe (sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.
The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.
lovastatin (Mevacor), atorvastatin Lipitor, simvastatin Zocor, simvastatin/ezetimibe (Vytorin)
Antihistamines: fexofenadine (Allegra), (terfenadine (Seldane), taken off the U.S.
The earlier mentioned side effect caused by the group of medications known as the statins, which Vytorin (ezetimibe/simvastatin) is a member of, is called rhabdomyolysis. This condition is breakdown of the muscle and has been associated with the statins as a class as a rare but serious side effect. Rhabdomyolysis caused by statins is reversible once the medication has been discontinued.
Can someone explain what, if any, evidence there for a switch from simvastatin to pravastatin? My husband's doctor said there is new evidence that simvastatin may be detrimental. Unfortunately, my husband did not quiz him further. He already has one stent in a narrow back artery but he has brought his cholesterol down considerably with the statins.
I have been taking simvastatin for three weeks since having a Tia but have also had a flu like cold for ten days , I am still having aching flu like pains which I would have thought would have passed by now . I don't know if this is a side effect of the drug I'm taking 40mg a day but feel really achy will this pass .
Zosta -10) also has the same effect as Storvas 10 mg. I have had cholecystectomy about 5 years back.
I have been taking Simvastatin 20mg for about 2 years, but recently my bad cholesterol has gotten very high to where it is elevated. Now, I admit to not being consistent lately with taking my medication; could this be the cause for my cholesterol to skyrocket?
The use of simvastatin in the prevention of a malignant liver tumor according to the present invention contemplates the daily administration of an effective amount of simvastatin orally. An effective amount of simvastatin is that amount which provides a decrease in the level of alphafetoprotein to a normal level and which maintains alphafetoprotein at the normal level.
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