Ezetimibe side effects
Common Questions and Answers about Ezetimibe side effects
zetia
According to Wikipedia, Ezetimibe has side effect - "it increased the thickness of artery walls and caused more major cardiovascular events"
So in summary, ezetimibe or irbesartan are no match to the power of myrcludex to inhibit ntcp, but it needs to be blocked so strongly, that the side effects from impairment of its natural function become the limiting factor.
The experiments with the chimeric mice used a dose of 2mg per kg and the human part of the chimeric liver only contains ntcp and needs to be blocked. The mouse liver has other transporters to clear the bile acids from the portal blood and furthermore, mice do not complain.
These still have significant side effects, but may be worth discussing with your prescriber. Outside of drug therapy, try taking a look at dairy products that are marketed as containing plant sterols. The evidence to support the fact that these products can help to reduce cholesterol is relatively strong.
Hi there and thanks for your question and joining the forum. Please always check in with your doctor on these matters so they can guide you. Unusual tiredness and weakness is listed as a 'less common' side effect of Simvastatin. https://www.mayoclinic.org/drugs-supplements/simvastatin-oral-route/side-effects/drg-20069006. For most people it doesn't cause significant issues, however. With all medications, weighing risks and benefits to taking the medication must be done.
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
The FDA-approved drug ezetimibe (sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.
The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.
Vytorin does a remarkable job of reducing your Cholesterol, much better than Zocor (Simvastatin) alone. However, Zetia doesn't seem to add anything to the picture as far as preventing heart disease is concened. But read this about Zocor:
-"Zocor Users Not Warned of Risks:
The FDA's June 2011 safety alert is the most serious of many warnings regarding Zocor and associated risks of myopathy and rhabdomyolysis. Zocor manufacturer Merck & Co.
I understand your concern, but after much research concerning the side effects of statins meds, PVC's are not a listed side effect. In fact, statin use has been studied in exercise induced PVC trials and have been shown to reduce the incidence of PVCs due to exercise so it would stand to reason that they also do not affect normal heart rhythm.
Having said that, your PVCs may be anxiety related to statin use.
You could consider going for a higher dose of Lipitor, another way to go is to consider taking a drug that limits cholesterol absorption such as Ezetimibe. There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor.
Best of luck to you. Stay positive.
“Once the animals were put on the drug, we were able to reverse the disease after a single month with no adverse side effects—while they ate a high-fat diet.”
Fatty liver, which often accompanies obesity and type 2 diabetes, frequently leads to more serious conditions including cirrhosis and liver cancer. The condition affects some 10 to 24 percent of the general population, according to a 2003 study in GUT, an international journal of gastroenterology and hepatology.
Fatigue and lethargy are side effects of atenolol, however, I do not see any information suggesting that muscle weakness is a side effect of atenolol. I see that you also take Vytorin. It appears that symptoms of ALS,( Lou Gehrig's Disease) have been reported to the FDA in a higher than expected number of patients taking statins. ALS is a progressive motor neuron disorder with symptoms such as difficulty walking or standing, difficulty with fine motor skills and muscle paralysis.
curious if stef2011 or studyforhope or StephenCastlecrag know whether simvastatin by itself can reduce viral load? I've read about the effects in conjunction with NUCS but I'm curious if sim is effective alone.
I will do that it seems the higher dose has created this and I'm not on anything else.
Many AD's have side effects that affect the libido, guess it applies to both sex es. As far as I know all AD's have this drastic effect . Hopefully you'll find one that's OK for you . Good luck.
Yes, I've only been on it a week and I experience the muscle aches and bilateral flank pain as well. In addition, insomnia!
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