Ezetimibe metabolism
Common Questions and Answers about Ezetimibe metabolism
zetia
Entry point for hepatitis C infection identified
January 24, 2012
A molecule embedded in the membrane of human liver cells that aids in cholesterol absorption also allows the entry of hepatitis C virus, the first step in hepatitis C infection, according to research at the University of Illinois at Chicago College of Medicine.
also statins like simvastatin were reported to boost response a little but better not mix 2 statins, in a report researchers of ezetimibe effect on hbv and hcv suggested the use of ezetimibe with interferon but without simvastin
ezetimibe dose is 10-20mg daily but human trials with dose 50mg daily for a limited time did not find any sides or toxicity
The FDA-approved drug ezetimibe (sold under the trade-name Zetia) is readily available and perfectly targeted to the receptor, Sainz said, so the researchers had an ideal method for testing NPC1L1's involvement in HCV infection.
The researchers showed that ezetimibe inhibited HCV infection in cell culture and in mice transplanted with human liver cells. And, unlike any currently available drugs, ezetimibe was able to inhibit infection by all six types of HCV.
You could consider going for a higher dose of Lipitor, another way to go is to consider taking a drug that limits cholesterol absorption such as Ezetimibe. There is a combination drug Simvastatin and ezetimibe that may be better in controlling cholesterol. Discuss these drugs with your doctor.
Best of luck to you. Stay positive.
A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
Does anyone know if having your Gallbladder removed slows down your metabolism? or does it speed it up? What have you experienced?
If you really want to kick-start your metabolism, you may also try dividing your meals up into smaller portions that you eat more often throughout the day. Every time you eat, it helps your metabolism rise, so as strange as it may sound, eating frequently can help you lose weight or maintain a healthy weight.
Take care!
no study for its activity on hbv, we do know it has activity but the trial has never started
simvastatin lowers hcc 50% and prevents fibrosis/cirrhosis so it is indicated on all hbver, this has thousands of pateints studied for decades to find this data on hcc
you better use simvastatin instead other statins, also ezetimibe has in vitro effect on hbv so these are the best choices on hbvers
I had a very similar situation to you, but before you think about more medication, you mention you are a smoker. Your metabolism including that of fats is very affected by a lack of vitamin C and smoking lowers vitamin C absorption in a smoker by around half. You say you have fruit juice in the morning, but try drinking more during the day, fresh fruit juice high in vitamin C should help a lot with many aspects.
The last couple years I have been watching myself so closely. I have noticed that hypo mania causes me to eat a lot and depressive states I hardly eat for days. I weight the same in my 40's as I did in my mid teens, most of the time. I normally weigh about 180 and am pretty fit, but months of mania in India lead to extreme situations that landed me at 130 pounds. I am trying to see if my appetite changes and then my mood, or if my mood affects my appetite.
I have trouble gaining weight because i have a super fast metabolism. I way 102 (wich is a good weight for my age) and i eat ALOT. My friends make fun of me for being skinny, i mean my legs look so skinny that my little brother mad fun of me which REALLY hurt my feelings. I am also nicknamed pencil because I DON'T have "curves" or "hips" and my ankles and calfs are super skinny.I hate being called that.
I'm not sure to whom you are addressing your question.
I haven't done a lot of research on the subject, but since hypothyroidism does affect metabolism, I'd guess that alcohol metabolism would be altered, just as food metabolism is altered.
Recommended
