I take Effexor XR, and while I understand it's a love it or hate it kind of medication, it's been a good one for me. That said, there are some downsides. Withdrawal hits hard and fast, so if you're a few hours late taking it, you'll know. Headaches that painkillers don't touch, dizziness.. I don't know how much worse it gets, because I've never left it longer than that, but all in all, it's been great.