Barbara- I tapered Effexor with a lot of difficulty. When I went off for two days, I was nuts, crying all the time and having the brain zaps. So, my psych put me on prozac for a few weeks. So far, it has helped a lot. I plan to go off all anti-depressants to get pregnant, but if you need something just to bridge the gap with Effexor, which is an SNRI, then prozac helps, even though it's an SSRI.