You don't state, specifically, how long you've been on the duloxetine, (Cymbalta). But it can take anywhere from one to four weeks, sometimes longer, for this med to reach therapeutic levels and for you to begin to notice some improvement. If it hasn't been this long, give it some more time, but I'd not let it go much over 6 weeks before getting back with my doctor. Finding the right antidepressant can be a real trial and error ordeal, but stick with it.