Rifampin, a hepatic enzyme inducer, is effective for the pruritus of cholestasis, but caution should be
used in patients with preexisting
liver disease because of possible hepatotoxicity. Butorphanol has also been shown to be effective in suppressing cholestatic pruritus. Zoloft (Sertraline), an antidepressant often prescribed to people with hepatitis C, is also effective
in reducing the itching caused by cholestatis
http://hcvadvocate.org/hepatitis/factsheets_pdf/pruritus.