Digoxin renal dosing
Common Questions and Answers about Digoxin renal dosing
digitek
Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
39% With Moderate Global LV Wall Hypokinesis
Normal Stress Myocardial Perfusion Imaging
Dilated LV
Negative Serial Cardiac Enzymes
No Evidence Of Perfusion Deficits
Normal EKG With Normal Sinus Rhythm
D-Dimer Less Than 150
Troponin First Set 0.015
Albumin: 3.2 g/dL (Low)
Calcium: 8.
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
I took Digoxin for a number of years in reponse to an atrial fibrillation event. My new physician did not feel I needed to be on it any longer. What are the side effects of discontinuing this medication? I have been off it for several months and some odd changes in my body.
s explanation where he states digoxin is used to treat irregular heartbeats. I was on digoxin for a few months following my congested heart failue event. It is my understanding the medication is used to increase contractility of the pumping chambers. My medication for stablizing heart rate is a beta blocker (coreg) and an ACE inhibitor.
My research: "Digoxin is contraindicated in patients with ventricular fibrillation.
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
However, in general calcium channel blockers and beta-blockers are preferred to digoxin. Digoxin has been around for a long time! I used Digoxin over 50 years ago for my PSVT, and my recollection was that it did little to prevent episodes. There are so many newer drugs now that are far more effective. My basic understanding of Digoxin is that it works on the heart's electrical system and decreases the heart rate, but increases each stroke volume.
i hev a question concerning digoxin....wat is its effect in the body. I mean its pharmacokinetic effects. i am having a hard time searching the net for it...
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
An ACE inhibitor, beta-blocker, together with a diuretic and digoxin are usually given for this. Regular follow-up with your doctor is highly recommended for monitoring. A cardiac rehabilitation program may also help. Discuss this with your doctor for proper management. take care and regards.
They list some reasons being long term bleeding, like from stomach ulcers, gram-negative sepsis, auto immune disorders, certain drugs like acetaminophen, quinidine, sulfa drugs, digoxin, vancomycin, valium, and nitroglycerine, renal disease and failure, chemo and radiation, and splenic sequestration
I am wondering if you are uneasy about taking digoxin. If so, I would ask you cardio if you can get by with just the TOPROL XL. Digoxin, xanax, toprol xl, and lisinoprol seems like a lot of stuff to be taking.
I am a runner and only take TOPROL XL 12.5mg. This knocks out my extra beats and really slows my heart down. A little seems to go a long way for me.
I am taking Digoxin for tachycardia--my cardiologist says that while there aren't good studies available for cardiac meds while pregnant Digoxin is believed to be safe. It is not a betablocker, however the dr felt the digoxin would be safer than a betablocker while preggo. Also the changes in your blood volume while pregnant may correct the tachycardia.
Recommended
