Digoxin dosing in renal failure
Common Questions and Answers about Digoxin dosing in renal failure
digitek
There are a few beta blockers with evidence in heart failure -- they are carvedilol, metoprolol XL, and bisoprolol (not really used in the US). Atenolol does not have any data to support its use in heart failure, so I would recommend a different agent (one of the above). Which one to choose depends on your blood pressure and ability to take twice daily dosing vs once daily.
Chlorthalidone is a perfectly fine diuretic, if you have blood pressure room to tolerate it.
Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia), has been reported with the use of VIREAD [See Adverse Reactions (6.2)].
It is recommended that creatinine clearance be calculated in all patients prior to initiating therapy and as clinically appropriate during therapy with VIREAD.
Hi,
Digoxin is administered in the treatment of Congestive heart failure . Diastolic blood pressure significantly decreased and systolic blood pressure significantly increased during overnight sleep in the digoxin phase .Heart rate decreased in the overnight sleeping phase . Digoxin significantly decreases diastolic blood pressure during overnight sleep in patients with congestive heart failure.
Although methadone and fentanyl are also heavily protein bound and as such require reduced dosing in patients with cirrhosis, the metabolism of these agents does not yield toxic metabolites, and hence they, along with hydromorphone, may be better tolerated37,38 (Table 2)."
".....Hydromorphone and fentanyl appear to be the least affected by renal dysfunction, and fentanyl has less hemodynamic disturbance (due to lack of histamine release associated with other opioids).
Life expectancy isn't something the doctors are willing to talk about when they have a patient that is suffering heart failure, as well as renal failure. I'm stage 4 heart failure, and stage 5 renal failure.
I have an ICD implant, and do dialysis 6 days a week, for 2 1/2 hours at a time. I take Coreg, 12.5 mg/pm on dialysis days, along with 160 mg of lasix/pm, which mainly is used to remove excess potassium from my system, which dialysis doesn't do.
Digoxin and Toprol act in different ways and do not induce the same effects. I have atrial fib and was prescribed amioderone.
I've posted this story a couple of other times, but I think in this case it needs to be repeated.
I have a friend who was taking lisinopril, and everytime he tried to do anything that required a bit of energy, such as walking through his house, his BP dropped to the point of taking him to his knees. He has since quit taking the lisinopril, but the effects most likely will be with him for the rest of his life.
My husband was on lisinopril for approx.
Retailers who carry Digitek should return the product to the place of purchase. Overdosing on this drug can be very dangerous. In fact, digoxin was used in a series of murders in the 1980’s and 90’s that were committed by a male nurse who claimed to have killed the patients to “end their suffering”.
Digoxin is a generic of digitek and it is the generic that has legal issues.
yesterday we noticed a patch of hair gone so took him to the vet had all the blood work done and this morning we received a call saying Tye was in renal failure and may only have a few months to live.we brought him into the vet to get SUB Q fluids and this is needed for the next few days he will get a special diet and have to take a water pill and antiacid as well as another medication i cant remember what it is called let alone what it is use for.
and was rescued from the streets in houston. she has renal failure and has really bad teeth. The problem is two different vets.said it would be too risky to put her to sleep to pull or work on her teeth. Her breath is really bad and I know she is in pain. My poor little girl needs some help. Does anyone have a suggestions?
Renal failure may be either chronic or acute. Chronic Renal Failure (CRF) is a progressive, irreversible deterioration of kidney function. Because cats hide their illnesses and the very early signs of CRF are subtle, this disease may only be recognized when the patient reaches the 70% deterioration level and more dramatic symptoms are observable. The seemingly sudden onset may appear to be an acute condition but is most often a crisis point of CRF.
My cat, Miss Kitty has just died from renal failure. We did not notice any symptoms except weight loss and as she was about 14,, we attributed this to being older. She was still active and eating, until one Friday night when she collapsed. We took her to an excellent vet who gave her aggressive treatment over a period of weeks, including IV fluids, saline,blood supplements, phosphorus blocker, CCRF supplements, KD cat food, and we also gave her Astro Oil.
I have 2 twin jack Russell terriers. today I was told one of them has renal failure. vet wanted to eutho him then and there. was totally unprepared. I brought him back home cause I can't afford the costs for an attempt to save him, which I know there is zero salvation. my question is this. I bought these twin brothers from a breeder at 12 weeks. they have never been apart since their birth. always butt and butt when they sleep. 11 yrs old.
He converted while in the ER and was told to take it in addition to his beta blocker. They had given him a pretty large dose of it while in the ER and he took 3 doses of the pill...he started feeling pretty bad. He went to his regular cardiologist today and he ran a blood test to check for toxicity and took him off of it. It sounds like a very nasty drug...thanks for the info. I can't understand why he was put on it.
my dad was taken off of it because his rate dropped below 60 beats and was causing him to be knocked out for most of the day when he went off of it his symptoms improved now its been 2 weeks and he is showing signs of loss of appitite,sleepiness,slow in speech, stomach acid, nasea Can the digoxin be retintroduced without any big adjustment to his chemistry?
org/posts/Dogs/4th-stage-renal-failure-in-my-dog/show/425814?
In general, acetaminophen at reduced dosing is a safe option. In patients with cirrhosis, nonsteroidal anti-inflammatory drugs should be avoided to avert renal failure, and opiates should be avoided or used sparingly, with low and infrequent dosing, to prevent encephalopathy.
...The greater the progression of liver dysfunction, the greater the impairment in drug metabolism.
Renal anomalies could be responsible for decreased or deranged renal function and may lead to renal failure. One working kidney is enough for normal functions of the body. It would be difficult to comment if your other symptoms could be related. I would suggest discussing the situation and the suggested management plan in detail with your treating nephrologist.
Hope this is helpful.
Take care!
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
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