Yes, I was on estrogen patches when I was first diagnosed with B6
toxicity,
and in fact had been slowing ramping up on the estrogen. Estrogen reportedly increases your need for B6, which seems counterintuitive, since I had more B6 toxicity with higher levels of estrogen. Perhaps estrogen causes B6 to store more readily in the muscle? I have no idea, but there IS an effect, somehow. Also, during my B6 toxicity recovery, things were always much worse before my period.