Lumbosacral radiculoplexus neuropathy (LRPN) is a multifocal, asymmetric, painful neuropathic disorder affecting multiple levels of lumbosacral plexus, nerve roots, and distal nerves that emerge from the plexus. The disorder was first described
in diabetic patients (DLRPN) and was later found to occur
in nondiabetic patients as well. There have been debates as to the pathogenesis of DLRPN and LRPN.