My psychiatrist said that Cymbalta targets both seretonin and norephinephrine, so it is generally better for treating patients who have both depression and anxiety. I'm torn, though, because I'm taking Lexapro and while I don't feel great in terms of anxiety, I am not in a constant state of anxiety, like I was a few months ago. If I start Wellbutrin, it will be in addition to the Lexapro, so I feel like the only thing I would have to lose by trying it is some bad side effects.