Cyclosporine neutropenia
Common Questions and Answers about Cyclosporine neutropenia
restasis
About 6 months ago, I was finally diagnosed and started taking cyclosporine 100 mg 2x day. After a week, I could eat like a normal person—just about anything I wanted. It was great, it even allowed me to travel to Europe. The cyclosporine I was taking was a powder in a capsule, apparently this has been taken off the market and instead I took the same medication, but it was in the form of a capsule with alcohol. Unfortunately, after a short time, I was right back to before treatment.
Yes I took Cyclosporine for my aquagenic urticaria, it helped so much but not enough to have a normal life :S but maybe for you its going to be different...
I am still on 100 mg 2x daily cyclosporine. My cyclosporine through levels have been lower, the last time they were at 79. I Have been on 300 mg ursodiol 3x daily for biliary stricture since tx. I lowered the dose to 300mg once daily but just recently raised it back to 300x 3 daily because right side discomfort an increase in bilirubin. My headaches and fluid in ears have gotten better, still have the vision issues but heart palpitations have also lessened.
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
Close to five years post liver transplant. No rejections, cyclosporine mono -therapy .Also take 300 mg ursodiol 3x daily for bile duct stricture. Vascular hyper-tensions are becoming a real concern. ie heart, palpitations . fluid in ears , vision problems that aren't related to my actual eyes, the opthamologist confirmed, Migraines that have actually gotten better lately. kidney function is still adequate. My liver is doing very good especially with hep-c..
I had a blood test yesterday and results show a WBC of 2.9 and also low neutrophils of .60 (meaning I have moderate neutropenia). All other values are within range.
I had a blood test done a year ago and everything was good then (WBC of 5.6).
I don't have a fever or additional symptoms and don't think I have a virus.
I have as few questions:
1. Could this be a normal swing in my WBC, is it fairly common for healthy people to drop low and bounce back up?
2.
and the vet will probably prescribe cyclosporine drops to help the eye produce more tears. Before you use the cyclosporine drops, be aware that they will sting your dogs eyes, and long term use may contribute to kidney disease...talk this over with your vet.
Since your dog is 12 years old, please have annual bloodwork done on him to assess liver and kidney functions...bloodwork should be done on all senior dogs.
Best Wishes for you and your dog.....
Are you currently on any medication like imatinib? The neutropenia can be due to your current medication. You can ask your hematologist for G-CSF injection if you have persistent neutropenia. Patients with CML are immunocompromised and can easily acquire infections. Neutropenia also puts a patient in an immunocompromised state.
For now, it is very important to prevent acquiring any infection. You should avoid crowded places and persons with ongoing infection.
Good luck.
In an additional 33 patients, glomerular and tubular NEP protein levels from renal graft biopsies were significantly higher among the 13 patients receiving cyclosporine + EC-MPS than among the 12 patients receiving cyclosporine + azathioprine or 8 patients receiving cyclosporine alone. Glomerular NEP expression inversely correlated with glomerulosclerosis and proteinuria, and tubular NEP expression inversely correlated with interstitial fibrosis.
I am currently under St Thomas hospital for this, they are stating I should take Cyclosporine for 6 months, I was wondering if someone on here has taken this treatment and it has worked for them??, I am not convinced on this medication as I have read so many bad things about it.
My consultant has stated that 70% of people whilst on cyclosporine will be clear, one third will have total remission,one third will be same as before, one third will be worse once the treatment has stopped.
re considering an interferon dose reduction?? If neutropenia, the following applies to Inf/Riba, not the PIs.
Neutropenia frequently complicates IFN-based antiviral therapy for hepatitis C [14]. The relationship between neutropenia and infectious complications in this instance is not well described.
Hello all, I'm not sure if everyone is familiar with my story but I have neutropenia and graves disease. I need to get my wisdom tooth extracted because I have avoided it long enough. When I first tried to get my wisdom pulled the dental surgeon realized that my wisdom tooth was in my nerve and that i would suffer damage if pulled. I was told to prolong it as much as I could however, I get horrible migraines (I've suffered from migraines since 13) and I need my tooth taken out.
We immediately put her on an antibiotic ointment and cyclosporine. It has been almost 10 days and while there is less discharge, she is still having some trouble opening her eye, she just keeps it closed (unless she gets excited). At some times you look at her and she looks completely fine, others times she can barely open her eye. Is this normal for KCS? Should we have seen some major improvement by now?
I was switched to cyclosporine and Myfortic. When the Incivek was started my cyclosporine was dropped to 25 mg once per day due to their interaction. Due to my previous non-response and to the multiple variations of the HCV I carry my odds were considered to be about 30%, maybe 40% at best. At the end of week 4 the HCV RNA was not detectable. The only additional side effect is that the anemia came quicker this time. I will start Procrit injections probably sometime this week.
My 17 month old son just had 2nd blood test come back with low neutrophils and high lymphocytes. The doctor said something about neutropenia? Should i be worried or is this just sign of a virus?
Normal banded neutrophil count is 1,500 cells per microliter. A count between 500-1000, is a grade 3 risk of neutropenia, or low neutrophil count, with risk for infection.
Actually on the first day of fever and even for a day or two, initially when there is an infection, there is slight neutropenia. Then the body fights the infection and the neutrophils rise and by day five of fever most blood pictures will show increased neutrophil count.
t swelling and foamy urine. Now that I have a diagnosis, I am on pill forms of Prednisone every other day and Cyclosporine 2x every day. I have been on the meds for over 1 1/2 weeks and noticed that the foamy urine amount has doubled, my face swells unbelievably, and walking is difficult, as the bottom of my feet and ankles cause me severe pain. I checked with my Nephrologist and she states that it will take a little while for my body to adjust to the medicine.
I have been taking Restasis regularly for 2 months now for dry eye treatment. I usually put two drops in my eye at a time instead of just 1. It says it has "Cyclosporine Opthalmic Emulsion .05%. I have taken two Oraquick home tests and they both came up negative for hiv. Would the Cyclosporine be able to cause a false negative?
Did I develop neutropenia from the Graves disease and how do I stop the neutropenia from getting worse? Also, what are some things that I should avoid as a result of my neutropenia? In addition, my heart rate ranges from 120-140 and I feel very tired and confused. Are these feelings a result of my heart rate? Thank you in advance.
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