Immediately after
injection, I take a very soft, warm wash cloth and gently rub my
injection site in a circular motion to disperse the medication.
I've never experienced any site reactions. And I haven't had any burning, at all.
On Copaxone, I burned for an hour, and I had huge welts, that itched like crazy!
Hope that helps.
I'm sure members that have been using Rebif longer than I have will give you more advice.
Good Luck!