I think it really comes down to being honest about what you can religiously adhere to, potentially
long-
term. Just using my own thought process as an example, for me Copaxone was immediately off the list. Why? Because I know myself enough to know something I had to administer daily was most likely to be occasionally forgotten, resented, ignored. Also, to be honest, I was young, vain, and was really put off by the lipoatrophy potential.