Initially the sting was quite intense and I did have large bumps, warm to the touch, at the
injection site. For the first couple of months I warmed the
site pre-
injection, and iced afterwards, as suggested by SS and the nurse at my MS clinic. As my body adjusted to the drug, the pain and lumps greatly decreased and I didn't bother with the heat and ice. Nowadays, I only occasionally have a painful injection or small lump; most of the time, there's little if any reaction.