I was in this bottom 3% and after two attempts, ruling out any other possible culprits (normal baseline, then no alcohol, supplements or any other medication for the trial run on Rebif), I went off Rebif at the advice of my neuro, who treated this all very seriously,
and went on
Copaxone June of 2008. My liver enzymes promptly returned to normal,
and I am tolerating this med well ; it has no neg effect on the liver.