I had mine with the two-drug combination that my gastroenterologist usually uses, and it was a painless experience. However, my
colon was too twisted and he was not able to get the scope through. I could hear myself saying, "Ow, Ow, Ow, Ow," and I knew where I was and that I was having colonoscopy, but I was peacefully relaxed and unconcerned. The MD upped my medication twice, and still couldn't get the scope through.