All large and giant-breed dogs who happen to have black coats are suseptible to a toe cancer called squamous cell carcinoma (SCC). A study is ongoing at the University of Guelph
, Ontario, Canada, gathering statistics of dogs whose toes are affected.
My black Standard Poodle has just gone through his second surgery to remove a toe due to SCC. He lost his first toe, on a back foot, in 2008, after we discovered a lesion next to his toenail which refused to heal.