There are liver cleanses, colon cleanses, kidney cleanses -- they can be very good for health, but not very useful for losing weight in a healthy fashion because the weight will just come back as soon as you return to
your normal way of eating. The only way to
lose weight long-term is to
change your metabolism, which doesn't involve calories as much as it involves what you eat and how quickly it turns into sugar and how easily it moves through your digestive system.