Patients whose AFP levels reached 1,000 ng/mL had a 12% one-year survival rate
and only a 1% five-year survival rate
. These patients had an adjusted hazard ratio (HR) of mortality of 4.35 compared with HCC patients with AFP levels below 10 ng/mL. Furthermore, patients’ mortality risk grew incrementally with increasing AFP levels: mortality risk was 1.50 (95% CI, 1.22-1.83) in patients with AFP levels between 10 and 100 ng/mL and 2.23 (95% CI, 1.80-2.