Moreover, the apparent favorable effect of
coffee drinking was found both in
studies from southern Europe, where
coffee is widely consumed, and from Japan, where coffee consumption is less frequent, and in subjects with chronic liver disease."
The overall relative risk for coffee drinkers vs nondrinkers was 0.59 (95% CI, 0.49 - 0.72) with significant heterogeneity between studies. The overall relative risk for an increase in 1 cup of coffee per day was 0.77 (95% CI, 0.72 - 0.82).