Your physician may choose to treat the bumps with other topical medications, such as metronidazole,
erythromycin, benzoyl peroxide, tacrolimus, clindamycin, or pimecrolimus.
In more severe cases, oral antibiotics (such as tetracycline, doxycycline, minocycline, or erythromycin) may be required. Perioral dermatitis is a difficult condition to treat effectively. It often requires several months of treatment.