Heart burn/indigestion is often a sign of acid reflux from the stomach, which can occur at rest or
with exercise, and is often associated
with asthma.
The most worrisome causes of chest pain, shortness of breath and tightening of the chest would be disease of the blood vessels of the heart, also known as coronary artery disease (CAD), and blood clots to the lungs, also known as pulmonary emboli (PE).