Candesartan pharmacokinetics
Common Questions and Answers about Candesartan pharmacokinetics
atacand
- Absorption, oral: time to peak concentration 7h
- Elimination half-life = 12 h
(It says also that in general it can be administered once daily because it has a 24 h effect.Why?)
- Can you give another example to clarify it better please?
- When it says divide in 2 doses , does it mean only in the morning and dinner? 3 doses (morning-lunch-dinner)?
Thank you for taking the time to answer!!
I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out.
I'd query Schering-Plough as well as your hepatologist, if I were you.
Please give me a heads-up if you solve the riddle.
I get that dry cough too.
I don't take an ACE inhibitor though, I don't think. Just Lopressor, Dyazide/Maxzide, Lipitor and aspirin for the heart issues.
For me it started a couple of years ago one summer after pushing myself too hard. I start coughing out of the blue to the point of either just about passing out or vomiting mucus. Urgg My chest hurts and feels sunken in, pounds very hard and quivers sort of and then I'm fine till it happens again.
Hepatic Impairment
In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
The Phase 1 trial was designed to characterize the safety profile of ARC-520 across a range of doses and evaluate pharmacokinetics. It is a single-center, randomized, double-blind, placebo-controlled, single dose-escalation, first-in-human study of ARC-520 administered intravenously to healthy adult volunteers. All subjects have been dosed and received either placebo or ARC-520 in doses ranging from 0.01 mg/kg to 2 mg/kg.
i believe in the pre-clinical trials with healthy volunteers, researchers used Carbon14 to gauge the half-life and paths of elimination during pharmacokinetics studies. it is a common practice. perhaps that is what you are thinking about?
It may be replaced with valsartan or candesartan which do not usually cause this side effect. The verapamil usually does not cause this side effect. This may not be related to your medications, and chronic cough or ' bronchial asthma' may actually be cardiac in nature ( e.g. CHF). Make sure your physician takes this other consideration into account.
Nitazoxanide, brand name alinia, had also excellent ed50 results in an in vitro inhibition study, just as good as lamuvidine, so this sounded fascinating for a possible combination towards true synergism, to finally suppress virion production to a level so low that the silent daily reinfection will be reduced, allowing a slow net clearance of infected cells with a resulting drop in surface antigen.
Completely absorbed from the GI tract. Sodium salt (Anaprox) is more rapidly absorbed.
Distribution: Crosses the placenta; enters breast milk in low concentrations.
Protein Binding: >99%.
Metabolism and Excretion: Mostly metabolized by the liver.
Half-life: 10–20 hr.
CONTRAINDICATIONS AND PRECAUTIONS
Contraindicated in:
Hypersensitivity
Cross-sensitivity may occur with other NSAIDs, including aspirin
Active GI bleeding
Ulcer disease.
I suffer allergic reactions to blood pressure medications. Over a long period I have tried a huge number of different BP meds, and not found one that eventually didn't make me feel unwell. The most recent, Candesartan, lowered my BP in the first few days, but after that it gradually rose again to a point where my BP was way above normal levels and I was suffering severe chest pains..
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