Candesartan in heart failure assessment of reduction in mortality and morbidity
Common Questions and Answers about Candesartan in heart failure assessment of reduction in mortality and morbidity
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Although results are comparable among older and younger patients, old age is generally considered a significant risk factor for early mortality and morbidity, partly because of the high incidence of coexisting disorders in elderly patients. However, in many elderly patients, survival and quality of life can be improved with valve replacement or repair.
The overall perioperative mortality rate for aortic valve replacement in elderly patients is 10.
insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program." Circulation. 2007 Aug 7;116(6):627-36. Epub 2007 Jul 16.
Flegal KM, Graubard BI, Williamson DF, Gail MH. "Excess deaths associated with underweight, overweight, and obesity." JAMA. 2005 Apr 20;293(15):1861-7.
Temkin SM, Pezzullo JC, Hellmann M, Lee YC, Abulafia O.
Recently, in a randomized trial in 55 patients, CPAP therapy for 3 months improved ventricular function and reduced sympathetic activity in patients with heart failure and obstructive sleep apnea (OSA). Likewise, CPAP therapy in OSA patients reduced daytime blood pressure and heart rate, and was associated with a significant reduction in left ventricular end-systolic dimensions and increases in ejection fraction."
Source: http://eurheartjsupp.oxfordjournals.
It is a key physiological determinant of filling capacity (preload and is fundamental to the study of the pathophysiology of ventricular remodeling in heart failure and in response to surgical, pharmacological, or device-based treatment strategies.
LVEDP is independant of LVEF (pumping functionality). For some insight and a statistics from a study of in-hospital mortality.
Drugs like Enalapril and Candesartan, while often thought of as medications for treating high blood pressure, also have a proven role in the treatment of congestive heart failure. If your father is feeling unwell, and you think it is related to the medications, you should have him seen by his doctor. Also, be sure to mention to his doctor any over-the-counter supplements that he may be taking.
Arterial hypertension is a significant risk factor for late cardiovascular morbidity and mortality after repair of coarctation (obstruction) of the aorta. The commonest causes of late death are ruptured aortic aneurysm, cerebrovascular events (atherosclerotic and hypertensive), coronary artery disease and cardiac failure.
The LIFE study demonstrated that losartan was significantly superior to atenolol in the primary prevention of adverse cardiovascular events (myocardial infarction or stroke), with a significant reduction in cardiovascular morbidity and mortality for a comparable reduction in blood pressure".
The generic for losartan is cozar, and medication is about $10.00 for 90 day supply.
The effect of diet and exercise may be useful due to a decreased incidence of diabetes – which is a common co-morbidity with prostatic enlargement. Increased activity and alcohol in moderation may be protective. The exact role of cholesterol, hypertension, and smoking is not yet clear (best avoid the cigarettes though – as there is an association with prostate cancer mortality).
Also a heart rate sustained above 100 bpm at rest stresses the heart and can cause heart enlargement and impair contractions resulting in heart failure and it can cause arrhythmia (irregular beats).
You should be concerned and correct the underlying cause. If you can't tolerate medication, you may require an ICD.
For a perspective, electrical impulses from the heart muscle cause your heart to beat (contract).
If the heart is having problems filling or pumping (diastolic or systolic heart failure), stroke volume and cardiac output during a supraventricular tachycardia can drop too low, which is dangerous.
But in healthy hearts, supraventricular tachycardia is more of a nuisance. Given that the heart rate isn't extremely rapid (far above the estimated maximal heart rate) or causing problems like fainting. If it does, it's dangerous.
I had a run of supraventricular tachycardia at approx.
Plaque assessment can be done by CT scan angioplaty (images of the anatomy of heart coronary vessels for soft plaque (between the linings of the vessel) and hard plaque that resides in the heart channel that can reduce the flow of blood.
Then there is a cath angioplasty and that entails running an instrument through a vessel and into the heart to exam whether there is any plaque blockage.
Procedures usually are done if the patient is having chest pains that are believe to be vascular blockage.
t harmful in these patients, and that they may even diminish morbidity and mortality for liver patients with heart disease, Kumar said.
So she and colleagues looked at data from the Partners Research Patient Data Registry on a total of 243 patients, 81 of whom were treated for dyslipidemia with statins for at least 3 months, and 162 who served as controls matched for age, gender, and liver disease severity.
the largest mass poisoning of a population in history... beyond the accidents at Bhopal, India, in 1984, and Chernobyl, Ukraine, in 1986."
Well-meaning development groups had encouraged remote villages across Bangladesh to dig wells over the past decades, rather than rely on potentially contaminated surface water and dirty rivers. But now potentially a much worse problem has been found far below the surface.
Arsenic is a deadly poison with a history of use in intrigue and assassination.
Hi,
The main goals of treatment in angina pectoris are relief of symptoms, slowing progression of the disease, and reduction of future events, especially heart attacks and of course death. An aspirin (75 mg to 100 mg) per day has been shown to be beneficial for all patients with stable angina that have no problems with its use. Beta blockers (eg. carvedilol, propranolol, atenolol etc.
Beta-blockers have long being used as first-line therapy for hypertension as their use had resulted in a reduction in cardiovascular morbidity and mortality in controlled clinical trials. A recent meta-analysis comparing beta-blockers to all other anti-hypertensive drugs taken together has found that stroke reduction was sub-optimal. Specifically, atenolol was associated with a 26% higher risk of stroke compared with other drugs.
Given that portal hypertension is one of the main factors responsible for the complications of cirrhosis, the importance of measurements of hepatic venous pressure gradient (HVPG) (an estimation of portal hypertension) at the time of diagnosis of cirrhosis in predicting mortality in cirrhosis is important and has not been sufficiently analysed, particularly in the setting of other recognized predictors of death in cirrhosis (1).
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June 25, 2007 (Rio de Janeiro) — Experts debated the aspects of donor morbidity and mortality associated with live liver donation at the 13th Annual International Congress of the International Liver Transplantation Society, where the risk for the donor is an issue of major concern.
With increasing shortages of available liver grafts from deceased donation, living donations have become an increasingly valuable commodity.
If this is HR CRP, then you would fall into the high cardiovascular mortality risk group, regardless of you cholesterol findings. The only caveat in that is that you had a recent pregnancy and delivery and probably lots of stress related to having a newborn. The HTN also does not help. I would probably recheck this in a few months.
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