Other medical/psychiatric conditions I have are hypothyroidism and bi-polar disorder/depression for which I take levothyroxine (Synthroid), divalproex (Depakote) and
bupropion (Welbutrin). The medication information
for the Medrol dose-pack states cautious use in those with hypothyroidism, psychiatric history, being treated with an anti-convulsant, and on bupropion, as it could produce mood changes and affect the seizure threshold.