However, CNS stimulants can also increase blood pressure, heart rate, and body temperature, in addition to effecting our mood, appetite, and sleep pattern.
post marketing reports, methylphenidate had caused sudden death in
children and teenagers
, especially if they have preconditioned heart problems. FDA placed a black box warning on methylphenidate. Regarding its effect on male reproductive system, there are animals studies that shown methylphenidate may be carcinogenic at high doses.