does not exhibit antiviral activity against HCV at conventional
doses: a pilot clinical trial.
O'Leary JG, Chan JL, McMahon CM, Chung RT.
Gastrointestinal Unit, Department of Medicine, Harvard Medical School,
Massachusetts General Hospital, Boston, MA, USA.
Cholesterol biosynthesis is an integral part of HCV RNA replication. Not only
does HCV RNA replicate on lipid rafts, but it also requires cholesterol
intermediates to replicate.