Atorvastatin and pravastatin
Common Questions and Answers about Atorvastatin and pravastatin
lipitor
Two recent trials have compared the clinical outcomes of intensive lipid lowering with atorvastatin 80 mg/day and standard lowering with pravastatin 40 mg/day. In the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT) trial, patients with acute coronary artery syndromes were enrolled, and pravastatin lowered the low-density lipoprotein (LDL)-cholesterol to 2.46 mmol/l, whereas atorvastatin lowered it to 1.60 mmol/l.
Red yeast rice, which contains lovastatin, should also be avoided during treatment with telaprevir. Fluvastatin, pravastatin, pitavastatin, and rosuvastatin are probably safer alternatives, since they are not metabolized by CYP450 3A4. All patients treated with HMG-CoA reductase inhibitors should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.
Lisinopril and Carvedilol are blood pressure medications (lisinopril is an ACE inhibitor, Carvedilol is a beta blocker) and should not have any effect on your lipid profile. Both are important medications for those who have suffered a heart attack and undergone stenting. In addition to these medications, you should be on some sort of lipid medication (a "statin" such as atorvastatin, pravastatin, rosuvasatin, lovastatin, etc).
a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. 2
This was a single center, randomized clinical trial of 161 patients with mean age of 60 years and 46% with known cardiovascular disease. The effects of atorvastatin 80 mg/d and pravastatin 40 mg/d on CIMT were compared. Baseline CIMT and other characteristics were similar in both groups.
Pulse pressure is the difference in blood pressure between the systolic blood pressure and the diastolic blood pressure. Pulse pressure in healthy adults in a sitting position is about 40 mmHg. Your have a wide pulse pressure of 93mmHg.
//www.drugs.com/sfx/pravastatin-side-effects.html#consumer_Pravastatin
Have you discussed this with your doctor? If you take other drugs and/or supplements check with your pharmacist regarding drug interactions.
I recently was prescripbed pravastatin and I notice a higher number when I test after a night of fasting in my Blood Glucose. Is there a posibility that could cause the rise.
It seems that the main problem was with fenofibrate and pravastatin. The level was pravastatin was greatly increased. But newer info with other statins shows no danger. Atorvastatin serum levels were actually decreased.
Jack is very correct that any individual's response can vary a lot from the norm.
> Any other natural suggestions on lowering [TG]?
I've seen studies that low carb works best, but low Glycemic Index is not that far behind.
The study found that the patients on simvastatin achieved the target LDL level of less than 130, more than those on pravastatin (65 percent on simvastatin versus 35 percent on pravastatin). The most common side effects of the statins in general are nausea, gas, and upset stomach. Less common are headache, dizziness, rash, sleep disturbances, muscle pain, cramps, or weakness.
Never in my family history. Also thyroid gland not producing enough. Then i was asked about Atorvastatin and these issues especially typ 2 diabetes. Its all over the internet but my doctors don't seem to know much about the possible connection. What can i be told about this and further how does one investigate and gain knowledge to make a good decision. I am still taking it and don't know what to do. I am following drs orders at this time.
Review Article: Prescribing Medications in Patients With Cirrhosis
A Practical Guide
"....Statins. There continues to be a controversy over the use of HMG Co-A reductase inhibitors (statins) in patients with CLD and cirrhosis, mostly due to a concern of causing acute-on-chronic liver injury.
59 yo white male. 1 year post MI with two stents in my RCA. I am active and with high a normal BMI of 25 No problem walking a fast mile or with light exercise. My LVEF was 50% right after MI and 45% 2 months later. due for another echo in 2 months. my lipids are under control - LDL < 70 and TC < 140, with or without the 10 mg pravastatin I am prescribed as I eat mostly a quality plant based diet, low in fats and simple carbs..
My question has to do with drugs.
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This med is generic for Lipitor, as you probably already know. I've researched and there is nothing about anger problems. The best thing to do is ask your Dr or pharmacist if this could be a possible interaction.
When did you start the Zoloft? I'm asking because anger and personality chances could be a side effect of this med.
I was on 40mg of Pravastatin and now am on 80mg. Is my doc just being aggressive? Or is there another reason for the big increase? I welcome any speculations.
t seem overly concerned. He said I could go off the pravastatin and see how my numbers were with diet and exercise alone. I have been on a good routine with proper diet and regular exercise and I am at the low end of my healthy weight. I have low to normal blood pressure. Anyway, searching for info on this today, I can't find anyone with such low LDL levels but the term "dangerously low" pops up for women with HDL less than 40.
m still trying to get a clarification. Anyway, the cardiologist put me on Amlodopine and Pravastatin. Now, on a daily basis it seems, my heart rate increases and beats at 90-115 bpm (normally in the mid 70s).
At the same time, I've started on a vegetarian diet to try to lower my cholesterol. To try to make sure I get enough protein, I am using a protein drink (10-14 gr protein each). I drink 1-2 of these per day.
It has dropped my LDL to 39-45 range and blood glucose ranges from 105-111 fasting. A1c 5.1 - 5.3. Prior to the statin I was below 100. I am not overweight, exercise consistently and eat very healthy. So the statin is the culprit. I am wondering if being stricter on carb intake and supplementing with Berberine will help? Or has anyone had better outcomes with other statins like livalo or pravastatin?
t seem overly concerned. He said I could go off the pravastatin and see how my numbers were with diet and exercise alone. I have been on a good routine with proper diet and regular exercise and I am at the low end of my healthy weight. I have low to normal blood pressure. Anyway, searching for info on this today, I can't find anyone with such low LDL levels but the term "dangerously low" pops up for women with HDL less than 40.
It is easy to find information regarding drug-drug interactions for omeprazole (Prilosec) and atorvastatin (Lipitor). The omeprazole appears to increase the bioavailability of the statin, increasing the risk of side effects. Does this mean that the interaction is like taking a higher dose of the statin, which would provide benefit for someone like me who only takes a low dose (10mg atorvastatin daily) and has no statin tolerance issues?
FOR ME, it did nothing as it did almost nothing for the cholesterol levels, and in fact some test for liver function was bad and I was taken off the medication and switched to another. Hopefully that does not happen with you. Besides the other statin they switched me to the co-pay was several times the expense of the pravatstatin.
Average incidence per 10 000 person-years for monotherapy with atorvastatin, pravastatin, or simvastatin was 0.44%"
Here's the link;
http://jama.ama-assn.org/content/292/21/2585.full
It is extremely rare and is not associated with Zocor (Sivastatin) more than any other statin. Statins are being found to be much safer than previously thought. For instance, it has been determined that statins help increase liver function in individuals with liver disease.
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