atorvastatin and myopathy

Clinically, high levels of HMG-CoA reductase inhibitory activity in plasma may be associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death.

m insulin resistant. I am now taking 200mg of levothyroxine for hypothyroidism and 40mg of atorvastatin for cholesterol and fatty liver. I also take fish oil, multivitamin, D3, allegra, and baby aspirin. My medical provider is focusing on my thyroid before tackling everything else. I should also mention that my mother has non alcoholic cirrhosis of the liver, diabetes, dementia, diverticulitis, and myopathy. I'm considering taking coQ10.

Never in my family history. Also thyroid gland not producing enough. Then i was asked about Atorvastatin and these issues especially typ 2 diabetes. Its all over the internet but my doctors don't seem to know much about the possible connection. What can i be told about this and further how does one investigate and gain knowledge to make a good decision. I am still taking it and don't know what to do. I am following drs orders at this time.

Two recent trials have compared the clinical outcomes of intensive lipid lowering with atorvastatin 80 mg/day and standard lowering with pravastatin 40 mg/day. In the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT) trial, patients with acute coronary artery syndromes were enrolled, and pravastatin lowered the low-density lipoprotein (LDL)-cholesterol to 2.46 mmol/l, whereas atorvastatin lowered it to 1.60 mmol/l.

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This med is generic for Lipitor, as you probably already know. I've researched and there is nothing about anger problems. The best thing to do is ask your Dr or pharmacist if this could be a possible interaction. When did you start the Zoloft? I'm asking because anger and personality chances could be a side effect of this med.

I have had MS for 8 years now i was 35 when i was DX but, now my Mother was DX with Mitochondrial Myopathy and, i am scared this is what i have since its Genetic. How do they tell the difference between the 2 diseases? Should I be checked for the Myopathy? Does the Mitochondrial have lesions in the brain when a MRI is done. I have 19 lesions in my brain,brain stem,spine.

It is easy to find information regarding drug-drug interactions for omeprazole (Prilosec) and atorvastatin (Lipitor). The omeprazole appears to increase the bioavailability of the statin, increasing the risk of side effects. Does this mean that the interaction is like taking a higher dose of the statin, which would provide benefit for someone like me who only takes a low dose (10mg atorvastatin daily) and has no statin tolerance issues?

Yes, it looks like myopathy is a term for a multitude of muscular disorders and the cause needs to be determined. Sorry that you have that and Iwould seek a multitude of opinions on the cause if your'e not comfortable with the answer.

Muscle biopsy shows myopathy that occurs with anabolic steroid abuse, Also have MRI and tests for pituitary tumour nad and bloods for ? hypopituitary. Results show low testosterone consistant with anabolic steroid abuse. I have never used anabolic steroids at anytime. Could something internally be wrong. I have episodes of feeling unwell with sweats, hypoiglycaemic symptoms and low blood pressure.

What is steroid myopathy? What are the symptoms? Do you have to be on prednisone for a certain lenght of time? I have been on prednisone for 12yrs. I am just wondering!!!!!!!!

I have been having back pains for the past few months and lately, i have been experiencing tummy pains. I just had my blood test and the results are alarming. SGOT - 75 SGPT - 52 LDH - 293 CPK - 3,074 I have yet to see my doctor. but I am so worried now. Can you please help me? what do those results mean?

I have used 10mg Atorvastatin for years with no side effects. The doctor is switching me to simvastatin which reacted badly with my liver in the past. Aim is to save money. Is it safe to buy Atorvastatin online ?

The severe form of acute alcoholic myopathy is associated with the sudden onset of muscle pain, swelling, and weakness; a reddish tinge in the urine caused by myoglobin, a breakdown product of muscle excreted in the urine; and a rapid rise in muscle enzymes in the blood. Avoidance of alcohol is the main treatment available. Hope it helps.Take care and pls do keep me posted if you have any additional queries.Kind regards.

I had diabetes (type II) in the year 2004 and mild hypertension in the year 1996.My doctor has prescribed the following medicines from time to time.

If TSH is normal, then hard to conclude myopathy is thyroid related. T3 sometimes helps nonspecific muscle symptoms, but you have already tried this. Would consider looking into other causes as well of myopathy.

She is not alcoholically person and never drink in her live. She has heart disease and take atorvastatin for 10 years and also donepezil and ladiomil for 4 years. Since her doctor discover problem with GOT and GPT she stopped taking atorvastatin (3mounts before) because they were suspicious that atorvastatin was reason for this problem but again GOP and GPT increase. Next step was cancer marker (CA19-9 = 34.4, AST = 5.47, CEA=3.22) and virus markers (HBsAg Es = 0.13 negative, Anti-HCV = 0.

What is the statistic probability that Atorvastatin Ca will convert itself into his enantiomer? We believe that this conversion is improbable for 2 reasons First it requires breaking bonds in two different chiral sites in the molecule which will require substantial energy and will not happen spontaneously Second the statistical probability that the reforming of the bond in the enantiomer in this very specific way is close to zero. We would be appreciative to hear your opinion.

Hi, Centronuclear myopathy is a condition that primarily affects skeletal muscles and may be associated with mutations in the DNM2 gene (for autosomal dominant pattern) or mutations in the BIN1 gene (for autosomal recessive pattern) Patients with autosomal dominant centronuclear myopathy may have droopy eyelids(ptosis) and weakness in the muscles that control eye movement (ophthalmoplegia) --as mentioned in your other post. ( ref: http://ghr.nlm.nih.

since then i m taking the tablet regularly and now my trygleycerides level is 135 without any side effects. Please advise me whether i can discontinue taking this drug for some years to come or do i have to take it regularly life long.

I have muscle weakness of my upper arms and thighs and hips. Also my respiratory muscles are weak. I have tingling in my feet and arms. The other day I had this weird burning/tingling sensation in my right thigh and my right foot just started involuntary moving up and down. I also have dizziness and stumble sometime. I am seeing an ENT in April for this. When I saw my new neuro, I did have nystagmus, droopy eyelids and a positive Hoffman's sign. Anyway hoping to get some answers soon.

In mitochondrial myopathy, muscle biopsy shows abnormal stain in muscle fibres (red ragged). In addition, stains also detect absence of mitochondrial enzyme in mitochondrial myopathy. Therefore, in mitochondrial myopathy muscle biopsy can not be read normal. Hope this helps.

Since last few days I am observing that when I get up in the morning my tongue is coated white. I clean the tongue with a tooth brush and the white coating disappears and the tongue remains in natural pink colour throughout the day. Secondly, there is a small crack in the middle forefront of the tongue. My age is 81 years. I am not diabetic and my blood pressure is normal.

Atorvastatin and myopathy

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