Also, observe the half-life variations of the two drugs. The glucuronide metabolite of
Ativan carries a
half-
life of 18 hours, while Valium has a
half-life ranging from 24-100 hours. Therefore, it would be wise to gradually step the Ativan out while simultaneously stepping in the Valium. An example would look like this:
Days 1-5: Morning (Ativan 0.25 mg, Valium 2.5 mg)
Day 5: Valium, 5 mg, qd.
By gradually introducing the Valium, the potential for withdrawal is greatly reduced.