LAM and LdT not preferred due to high rate of drug resistance. End-point of treatment
– Seroconversion from HBeAg to anti
-HBe. Duration of therapy: IFN-a: 16 weeks; PegIFN-a: 48 weeks; LAM/ADV/ETV/LdT/TDF: minimum 1 year, continue for at least 6 months after HBeAg seroconversion; IFNa non-responders / contraindications to IFNa -> TDF/ETV.
If you are HBeAg-, HBV DNA (PCR) >20,000 IU/mL ALT >2 x ULN, then, IFN-a/peg IFN-a, LAM, ADV, ETV, TDF or LdT may be used as initial therapy.